360 TLR4 Plays An Important Role In Chronic Relapsing Pruritus Induced By Subcutaneous Capsaicin Injection In Neonatal Rats

Despite the high prevalence of chronic dermatitis and accompanied intractable itch, therapeutics that specifically target itching have low efficacy. Although toll-like receptors (TLRs) are suggested to contribute immune activation neural sensitization, their roles in itch skin remain elusive. Here, we show RBL-2H3 mast cell line expresses TLR4 treatment with a antagonist opposes LPS-dependent increase mRNA levels Th2 innate cytokines. The role pruritus was studied neonate rats which relapsing induced by neuronal damage following subcutaneous capsaicin injections. Treatment protected these from scratching behavior dermatitis. also restored density cutaneous nerve fibers inhibited histopathological changes associated after injection. Additionally, expression IL-1β, IL-4, IL-5, IL-10, IL-13 lesional decreased treatment. Based on data, propose reduction signaling cells fibers.